In vivo exposure to sodium arsenite produce hepato-nephro alterations, enzymatic inhibition, and neurobehavioral expression in Charles Foster rats

Abstract

Arsenic, a highly hazardous metalloid present ubiquitously in the Earth's crust, poses a significant threat to global groundwater contamination. This study aimed to
evaluate the hepato-nephro alterations, enzymatic inhibition, and neurobehavioral flux in Charles Foster rats exposed to arsenic. The rats were divided into control and arsenic-exposed groups, and their hepatic and renal functions were assessed. Enzymatic activity was measured to determine the inhibitory effects of arsenic, and neurobehavioral assessments were conducted to evaluate any behavioural changes. The results revealed significant alterations in hepatic and renal parameters, including biochemical and histopathological changes.
Enzymatic inhibition and neurobehavioral abnormalities were observed in the arsenic-exposed rats. These findings provide valuable insights into the toxic effects of arsenic on hepato-nephro function and neurobehavioral outcomes.