CORRELATION OF MICROVESSEL DENSITY AND EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA

Authors

  • Luís Antônio Nogueira dos Santos
  • Luciana Maria Pedreira Ramalho
  • Paulo Rogério Ferreti Bonan
  • Hercílio Martelli Júnior
  • Cláudio Janes dos Reis

DOI:

https://doi.org/10.7213/aor.v2i5/6.23016

Abstract

OBJECTIVES: The objectives of this study were to analyze the expression of the involved antibodies to p53 and CD31 and to verify the relation with histological grade of malignancy. METHODOLOGY: Eighteen cases of SCC had been studied, graduated for the system proposed by Anneroth et al (1). The p53 immunostaining was counting carried using ten fields for slide observing of 1000 positive and negative cells. The mensuration of angiogenesis was made through the counting of blood vessels and of the density of vases, which corresponds the occupied surface for field. RESULTS: 100% of the studied cases were positive for p53 with an average of 76% of the tumoral cells with nuclear protein accumulation and 71% for the CD31. The relation between the expression of p53 and CD31 and the histological gradation of malignancy was not observed. A positive correlation was observed in all the cases between the expression of p53 and an increase of the microvascular density. CONCLUSION: An increased p53 possitiveness and its association with angiogenesis in oral SCC is suggested in this study.

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Published

2006-11-28

How to Cite

dos Santos, L. A. N., Ramalho, L. M. P., Bonan, P. R. F., Martelli Júnior, H., & dos Reis, C. J. (2006). CORRELATION OF MICROVESSEL DENSITY AND EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA. Archives of Oral Research, 2(5/6). https://doi.org/10.7213/aor.v2i5/6.23016

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Articles