Cytological analysis of epithelial cells in adolescents with type 1 diabetes mellitus

Authors

  • Mônica Sommer Bittencourt
  • Ivana Maria Saes Busato
  • Milena Binhame Albini
  • Luciana Reis Azevedo-Alanis
  • Ana Maria Trindade Grégio
  • Antonio Adilson Soares de Lima
  • Maria Ângela Naval Machado

DOI:

https://doi.org/10.7213/archivesoforalresearch.09.002.AO06

Keywords:

Diabetes Mellitus, Type 1, Cytology, Mouth mucosa

Abstract


Introduction: Type 1 diabetes mellitus is a chronic metabolic disorder condition, which may causes oral mucosa changes in adolescents. The effect of glycemic control on the oral tissues has been scarcely reported as well as the low number of oral mucosal lesions found in this population. The goal of this study is to evaluate cytopathological changes in oral epithelial cells of adolescents with type 1 diabetes mellitus (DM1) and assess the glycemic control. Materials and methods: Oral smears were collected from normal mucosa by exfoliative cytology in 40 healthy adolescents and 40 with DM1. Cell morphology and cellularity were analyzed. Nuclear area (NA) and cytoplasmic area (CA) were measured; nuclear/cytoplasmic area ratio (NA/CA) was calculated. Time elapsed from the diagnosis of diabetes and glycated hemoglobin levels (HbA1c) were recorded. Results: There was no significant difference to NA, CA, NA/CA for both groups and also in relation to HbA1c (P > 0.05). No morphological differences were found among the groups (P > 0.05). There was a predominance of nucleated cells of the superficial layer in smears of both groups. Class I and Class II smears were predominant in both groups. Conclusion: This study revealed that type 1 diabetes mellitus and the glycemic control were unable to induce significant changes on oral epithelial cells in adolescents.

Downloads

Download data is not yet available.

Published

2013-11-28

How to Cite

Bittencourt, M. S., Busato, I. M. S., Albini, M. B., Azevedo-Alanis, L. R., Grégio, A. M. T., Lima, A. A. S. de, & Machado, M. Ângela N. (2013). Cytological analysis of epithelial cells in adolescents with type 1 diabetes mellitus. Archives of Oral Research, 9(2). https://doi.org/10.7213/archivesoforalresearch.09.002.AO06

Issue

Section

Articles