DNA damage and postural balance in multiple sclerosis patients

Autores

  • Karla Mendonça Menezes Universidade Federal de Santa Maria (UFSM)
  • Thaís Doeler Algarve Universidade Federal de Santa Maria (UFSM)
  • Fábio Saraiva Flôres Universidade Federal de Santa Maria (UFSM), Universidade de Lisboa (ULISBOA)
  • Ivana Beatrice Mânica Cruz Universidade Federal de Santa Maria (UFSM)
  • Fernando Copetti Universidade Federal de Santa Maria (UFSM)
  • Aron Ferreira Silveira Universidade Federal de Santa Maria (UFSM)

DOI:

https://doi.org/10.1590/1980-5918.030.S01.AO08

Resumo

Introduction: Multiple Sclerosis (MS) is a chronic inflammatory disease characterized by infiltration of inflammatory cells on the Central Nervous System (CNS). There is evidence that cumulative DNA damage can contribute to various mechanisms underlying MS lesions. Changes in postural balance are frequent observations in subjects with MS. Objective: Evaluated the DNA damage index (DDI)) and postural balance in patients with MS. Methods: A case-control study was conducted with 28 subjects matched for sex, age, and body mass index, divided into MS group and control. The DDI was assessed by comet assay and postural balance through recording the body oscillations of the center of pressure (COP), in the anterior-posterior and lateral middle directions. Results: Showed higher DDI in MS patients (21.3 ± 4.8) than controls (7.9 ± 6.1). Significant differences between groups were also noted in postural control parameters. The wider ranges of postural sway were observed in the MS group. The associations between DDI and postural control parameters showed weak, but significant correlations. No associations were found between DDI and time of diagnosis of MS. Conclusion: People with MS had higher DDI and larger body oscillations than healthy individuals.

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Publicado

2017-11-30

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