Histomorphometrical analysis on the effects of two therapeutic ultrasound intensities on fracture healing in aged rats [I]

Authors

  • Jeronimo Rafael Skau
  • Bruno Rodrigues
  • Felipe Oliveira Rosa
  • Rubens Correa Araujo
  • Renata Gabriel Fontinele
  • Romeu Rodrigues de Souza

DOI:

https://doi.org/10.1590/0103-5150.027.002.AO02

Abstract

Introduction: Experimental studies conducted in young animals show that therapeutic ultrasound (TUS) has been successfully used to shorten the healing time of bone fractures. However, they were not found in the literature, studies comparing the effect of different intensities of UST in aged animals. Objective: To test the efficacy of intensity 1.0 W/cm² and of 0.5 W/cm² in the consolidation of experimental fracture of the tibia from aged Wistar rats. Materials and methods: Three groups of 15 month old rats were submitted to a midshaft osteotomy of the tibia and then, the hind member was immobilized with a metal splint and plaster of Paris, wrapping the knee and ankle joint. One group (L), received ultrasound at 0.5 W/cm²; the other group (I), were exposed to ultrasound at 1.0 W/cm². One control group (C), did not receive the ultrasound. Fifteen animals (five from each group) were euthanatized at the end of the first week and fifteen (five from each group) at the end of the third week. The progress of the fracture healing was performed for each group by morphometric analysis of histological sections of the fracture region. Results and conclusion: The results showed that fractures treated with ultrasound at 1.0 W/cm2 healed significantly faster than did the fractures treated with ultrasound at 0.5 W/cm2 and the control.

Downloads

Download data is not yet available.

Downloads

Published

2017-09-18

Issue

Section

Original Article