POLY (METHYL METHACRYLATE) ABSORPTION ANDRELEASING OF NYSTATIN AND FLUCONAZOLE

Autores

  • Wander José da Silva
  • Letícia Machado Gonçalves
  • Fernanda Faot
  • Luiz Roberto Pimentel Trevizan
  • Altair Antoninha Del Bel Cury

DOI:

https://doi.org/10.7213/aor.v7i3.23095

Palavras-chave:

Dental prosthesis, Antifungal agents, Acrylic resins, Chromatography, High pressure liquid

Resumo


Objectives: The aim of this study was to verify if there are poly (methyl methacrylate) (PMMA) absorptionand releasing of nystatin (NYS) and fluconazole (FLZ) after simulated treatment of oral candidosis. Materialsand methods: Specimens (30 × 25 × 5 mm) prepared with PMMA polymerized by hot water bath or microwaveenergy were immersed into NYS (3.12 μg/mL), FLZ (2.56 μg/mL) or deionized water (control) during14 days at 35 ± 2 °C. After treatment simulation, specimens were immersed into distilled water during 3, 7, 10and 14 days. The immersion liquid was changed after each analysis. Higher performance liquid chromatographywas used in order to detect antifungal compounds. In order to determine if there was surface depositionof drugs on PMMA resin, specimens were analyzed with electronic microscopy (SEM). Results: None of theantifungal agents was released from the PMMA resins. Conclusion: Within the limitations of this study, itcould be concluded that PMMA resins had no drug absorption with posterior release.

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Publicado

2011-11-28

Como Citar

Silva, W. J. da, Gonçalves, L. M., Faot, F., Trevizan, L. R. P., & Cury, A. A. D. B. (2011). POLY (METHYL METHACRYLATE) ABSORPTION ANDRELEASING OF NYSTATIN AND FLUCONAZOLE. Archives of Oral Research, 7(3). https://doi.org/10.7213/aor.v7i3.23095

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