Physical exercise and metformin in the prevention of pre-eclampsia: systematic review
DOI:
https://doi.org/10.1590/1980-5918.033.AO41Abstract
Introduction: Pre-eclampsia is a disorder that may occur during pregnancy, but is still unknown and / or multifactorial causes. Objective: To verify whether physical exercise and metformin may be helpful in preventing preeclampsia. Method: This is a systematic review of the literature in Pub-Med / MEDLINE, Web of Science, Scopus , LILACS and Cochrane. This review followed the critiques of the PRISMA checklist. Bias assessment was used for the Cochrane handbook for systematical reviews of interventions (Version 5.1.0) for clinical trials and the Downs and Black scale for cohort and case-control studies. Results: 17 studies were within the established criteria. The subjects evaluated were: pre-eclampsia, cardiovascular metabolic factors, physiotherapeutic therapies and the effects of physical exercise and metformin on the circulatory system. Conclusion: There is a need for adapted techniques and new protocols according to the contingencies and complications of pregnancy. During pregnancy, it is suggested a greater interdisciplinarity of knowledge among professionals and that the therapy receives adjustments against the metabolic alterations of the reproductive system. In order to prevent preeclampsia, the study suggests a program of individual exercises that include greater assistance, verification and / or comprehension of possible changes and their limits during pregnancy. As well as, the adjuvant use of metformin of 1000 mg / d in the initial phase, with the purpose of maintaining the effects of the drug due to renal clearance during pregnancy, until reaching a maximum of 1500 mg / d, to avoid side effects of the drug.
Downloads
Downloads
How to Cite
Issue
Section
License
The authors guarantee that the works submitted to this journal are original and were not prepared in violation of any third party rights, having obtained all the necessary authorizations to include complementary content, such as, but not restricted to, translations, illustrations, tables and citations, whose precise sources the author also undertakes to indicate. The authors also declare that the works do not contain defamatory statements that violate morals, good customs and/or that violate intellectual property rights.
When submitting your paper, the Copyright Assignment signed by all authors must be attached.