Handgrip strength, functionality and plasma levels of IL-6 in elderly women

Authors

  • Daniele S Pereira
  • Viviane F Cipriano
  • Juleimar SC Amorim
  • Bárbara Z Queiroz
  • Diogo C Felício
  • Leani SM Pereira

DOI:

https://doi.org/10.1590/0103-5150.028.003.AO06

Abstract

Introduction: Aging is associated with a chronic low-grade inflammatory process characterized by an increased production of inflammatory mediators. These elevated levels are predictors for muscle function (sarcopenia) and deterioration of physical performance in the elderly. Objective: To investigate the correlation between sarcopenia, functional capacity, and interleukin-6 levels. Materials and methods: This crosssectional study assessed a convenience sample of elderly individuals (n = 130) using a handgrip dynamometer (JAMAR™), and the functional capacity test was performed by sitting and standing. Interleukin-6 levels were determined using high sensitivity ELISA kits. Spearman correlation coefficient was used to assess the correlation between these variables, at a significance level (α) of 0.05. Results: There was significant inverse correlation between strength and function (rS = -0.273, p = 0.002) such that elderly individuals with lower peak force took longer to perform the sit-to-stand test, in contrast with the relationship between plasma interleukin-6 levels and strength (rS = -0.043, p = 0.624) or functionality (rS = -0.060, p = 0.501). Conclusion: The outcome measures analyzed could predict the decline in muscle strength and functional capacity, and may be indicative of sarcopenia in elderly individuals. There was no correlation between the interleukin-6 levels and the grip strength and functional capacity of the sample investigated.

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Published

2017-09-20

How to Cite

Pereira, D. S., Cipriano, V. F., Amorim, J. S., Queiroz, B. Z., Felício, D. C., & Pereira, L. S. (2017). Handgrip strength, functionality and plasma levels of IL-6 in elderly women. Fisioterapia Em Movimento (Physical Therapy in Movement), 28(3). https://doi.org/10.1590/0103-5150.028.003.AO06

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Original Article

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